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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK3
All Species:
35.15
Human Site:
T155
Identified Species:
55.24
UniProt:
O43781
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43781
NP_001004023.1
588
65714
T155
K
Q
Y
K
H
H
L
T
A
Y
E
K
L
E
I
Chimpanzee
Pan troglodytes
XP_524527
588
65774
T155
K
Q
Y
K
H
H
L
T
A
Y
E
K
L
E
I
Rhesus Macaque
Macaca mulatta
XP_001086117
588
65769
T155
K
Q
Y
K
H
H
L
T
A
Y
E
K
L
E
I
Dog
Lupus familis
XP_537131
637
71340
T205
K
Q
Y
K
H
H
L
T
A
Y
E
K
L
E
I
Cat
Felis silvestris
Mouse
Mus musculus
Q922Y0
586
65553
T154
K
Q
Y
K
H
H
L
T
A
Y
E
K
L
E
I
Rat
Rattus norvegicus
Q4V8A3
586
65492
T154
K
Q
Y
K
H
H
L
T
A
Y
E
K
L
E
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
R137
L
G
P
N
A
K
K
R
L
G
A
A
G
G
P
Chicken
Gallus gallus
Q5ZIU3
526
59419
Q137
D
D
Q
G
S
Y
I
Q
V
P
H
D
H
I
A
Frog
Xenopus laevis
NP_001088793
567
63329
S135
K
Q
Y
K
H
Q
L
S
A
Y
E
L
Q
E
I
Zebra Danio
Brachydanio rerio
NP_001108400
581
65351
T146
K
Q
H
R
Q
Q
M
T
T
L
E
Q
Q
E
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
T223
I
L
Y
M
N
K
L
T
P
Y
E
R
T
E
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023207
817
89866
V407
Q
T
F
G
A
K
L
V
P
F
E
K
N
E
I
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
T139
K
L
Y
M
H
K
L
T
S
Y
E
H
H
E
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
G90
Y
N
G
L
P
R
Q
G
S
P
P
W
R
P
D
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
L267
D
E
V
Q
G
Q
K
L
S
I
P
Q
M
Q
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
85.7
N.A.
89.6
90.8
N.A.
57.9
59
65.3
63.4
N.A.
39
N.A.
40.5
54.7
Protein Similarity:
100
99.4
99.4
88.8
N.A.
93.5
94.2
N.A.
70.7
71.9
77.8
76.6
N.A.
50.9
N.A.
52.5
68.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
0
73.3
40
N.A.
46.6
N.A.
33.3
60
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
0
13.3
80
66.6
N.A.
60
N.A.
53.3
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.2
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
41
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
14
0
0
0
47
0
7
7
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
7
0
0
0
0
0
0
0
0
0
7
0
0
7
% D
% Glu:
0
7
0
0
0
0
0
0
0
0
74
0
0
74
0
% E
% Phe:
0
0
7
0
0
0
0
0
0
7
0
0
0
0
0
% F
% Gly:
0
7
7
14
7
0
0
7
0
7
0
0
7
7
0
% G
% His:
0
0
7
0
54
40
0
0
0
0
7
7
14
0
0
% H
% Ile:
7
0
0
0
0
0
7
0
0
7
0
0
0
7
74
% I
% Lys:
60
0
0
47
0
27
14
0
0
0
0
47
0
0
0
% K
% Leu:
7
14
0
7
0
0
67
7
7
7
0
7
40
0
7
% L
% Met:
0
0
0
14
0
0
7
0
0
0
0
0
7
0
0
% M
% Asn:
0
7
0
7
7
0
0
0
0
0
0
0
7
0
0
% N
% Pro:
0
0
7
0
7
0
0
0
14
14
14
0
0
7
7
% P
% Gln:
7
54
7
7
7
20
7
7
0
0
0
14
14
7
0
% Q
% Arg:
0
0
0
7
0
7
0
7
0
0
0
7
7
0
0
% R
% Ser:
0
0
0
0
7
0
0
7
20
0
0
0
0
0
0
% S
% Thr:
0
7
0
0
0
0
0
60
7
0
0
0
7
0
0
% T
% Val:
0
0
7
0
0
0
0
7
7
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
7
0
60
0
0
7
0
0
0
60
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _